FORMULATION DEVELOPMENT STUDIES ON GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM OF FORSKOLIN-A NATURAL ROOT EXTRACT OF COLEUS FORSKOHLII

摘要

In the present study, Forskolin, a natural root extract from the Coleus Forskohlii, was developed into a gastro retentive floating drug delivery system, using different grades of HPMC. The drug is used as anti-obesity agent reducing fat in body muscles. Forskolin increases cAMP accumulation, and therefore stimulates lipolysis. So, with high concentrations of forskolin, cAMP and lipolysis increases Enhanced lipolysis increases fat degradation and fat usage as a fuel in the body. This may promote fat and weight loss. It is thought that supplementing with forskolin may enhance fat loss without loss of muscle mass .Presently the drug is available in conventional capsule dosage form with effect on systolic blood pressure. In floating drug delivery ,the release rate of drug was controlled minimizing dose related side effects. The cumulative drug release was fitted in different kinetic models and statistically validated.