Aromatase inhibitors are approved hormonal agents for the treatment of breast cancer since the past few decades. These agents are usually well tolerated except some common side effects seen in day-to-day practice such as arthralgia and mood changes. Some of the side effects of these agents are still very uncommon and must be considered in differential diagnosis while evaluating these patients on follow-up as this therapy is usually taken for prolonged time period and careful risk–benefit assessment must be done before considering discontinuation of therapy. In this conversation, we report the occurrence of lichen sclerosis of oral cavity in an elderly female suffering from breast cancer who developed it while being on anastrozole therapy.
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