Sorption Characteristics of Anion-Exchange Resins Possessing ω-Oxoalkyl or ω-Hydroxyalkyl Spacer for Bile Acids

摘要

In order to evaluate anion-exchange resins possessing a spacer arm (ω-oxoalkyl(-CO(CH2)n-) or ω-hydroxyalkyl(-CH(OH)-(CH2)n-)) between the quaternary ammonium group and the polymer backbone, sorption behavior for bile acids was investigated for three series of resins prepared from polystyrene beads having different cross linkages. In the highly crosslinked resins, the resins having the spacer arms gave higher exchange capacities for bile acids than conventional-type resins did. The sorption was also affected by the length and chemical structure of the spacer arm. Thus, a spacer arm allows for more favorable sorption of sterically hindered anions.