Serum Nitric Oxide as Early Predictor of Poor Outcome in Neonatal Sepsis

摘要

Objective This study examines the serum nitric oxide (NO) as an indicator of poor outcome in neonatal sepsis. Study Design This prospective observational study was conducted in Dr. Hasan Sadikin General Hospital, Bandung, from September to November 2014. All subjects fulfilled inclusion criteria were tested serum NO metabolite at admission, then were followed up to determine the final outcome, grouped as Group I-good outcome, Group II-poor outcome. Logistic regression analysis was performed to determine independent variables associated with poor outcome, estimated as the odds ratio (OR) and the 95% confidence interval (95% CI). Results Fifty seven neonates were enrolled in this study. There was a good relation between NO level and poor outcome in neonatal sepsis (p<0.01). The level of NO metabolite was a significant independent factor of the poor outcome in neonatal sepsis in the multivariate regression logistic analysis (OR 25.975, p=0.000, 95% CI 4.354–154.952). It showed good discrimination with AUC 0.815 (95% CI 0.676 to 0.955), and good calibration (p=0.192). Conclusion A high serum NO level is independently associated with poor outcome in neonatal sepsis.