Advances in Non-Hodgkin’s Lymphoma

摘要

Non-Hodgkin lymphomas (NHLs) are a heterogeneousgroup of malignancies of the lymphoid system. Based onthe World Health Organization classification ofhematological and lymphoid tumors, NHLs are aheterogeneous group of lymphoproliferative disordersoriginating in B lymphocytes, T lymphocytes, or naturalkiller cells. At the NCCN 18th Annual Conference, Dr.Jeremy Abramson and Dr. Andrew Dr. Zelenetz discuss 3specific B-cell NHLs: follicular lymphoma, mantle celllymphoma, and chronic lymphocytic leukemia. Follicularlymphoma (FL) is the most common subtype of indolentNHL, accounting for approximately 22% of all newlydiagnosed cases of NHL. B-cell lymphomas account forapproximately 90% of all lymphomas, and the 2 mostcommon histological disease entities are follicularlymphoma and diffuse large B-cell lymphoma.Approximately 55,000 to 60,000 new cases of nonHodgkinlymphoma are diagnosed annually in the UnitedStates, a number that has nearly doubled during the past 3decades. Also, NHL arise either in lymph nodes and inother lymphatic tissues, such as the tonsils, spleen,Waldeyer’s ring and thymus (“nodal” lymphomas), or inlymphatic cells in other organs (“extra-nodal”lymphomas). (Epstein-Barr virus (EBV) is associated withseveral different types of aggressive non-Hodgkinlymphoma (NHL).