边缘性人格障碍是以持久而普遍的认知、情绪和行为失调为特征的一种严重而复杂的行为障碍。从发展心理病理学的视角来看，边缘性人格障碍与童年期不良家庭环境、混乱的依恋关系、家庭史因素等心理社会风险因素有关，也与5-羟色胺、多巴胺等神经递质的功能缺损，前额边缘环路失调，自主神经功能失调有关，尤其重要的是边缘性人格障碍的形成可能是环境风险因素与脆弱的神经生物因素交互作用共同影响的结果。对边缘性人格病因机制考察的未来研究应该更加注重追踪研究，从多层次、多领域考察心理社会因素与生物学因素的交互在BPD发病中的作用。 Borderline personality disorder (BPD), which is characterized by persistent and pervasive cognitive, emotional, and behavioral dysregulation, is among the most severe and perplexing behavioral disorders. From the developmental psychopathology approach, Borderline personality disorder is associated with psychological and social risk factors including poor family environments during childhood, disrupted attachment relationships and family history factors, and it is related to dysfunctional neurotransmitter systems, including serotonin, dopamine and so on. It is also related to dysfunction of frontolimbic circuitry and the peripheral nervous system. Most importantly, the emergence of BPD was the results of the interaction between environmental risk factors and vulnerable neurobiological factors across development. Future researches about pathogenetic mechanisms of the borderline personality disorder should focus on longitudinal or developmental studies and examine the role of the interaction between environmental risk factors and neurobiological factors in BPD from other fields and more comprehensive assessments of more methods.
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机译：边缘性人格障碍是以持久而普遍的认知、情绪和行为失调为特征的一种严重而复杂的行为障碍。从发展心理病理学的视角来看，边缘性人格障碍与童年期不良家庭环境、混乱的依恋关系、家庭史因素等心理社会风险因素有关，也与5-羟色胺、多巴胺等神经递质的功能缺损，前额边缘环路失调，自主神经功能失调有关，尤其重要的是边缘性人格障碍的形成可能是环境风险因素与脆弱的神经生物因素交互作用共同影响的结果。对边缘性人格病因机制考察的未来研究应该更加注重追踪研究，从多层次、多领域考察心理社会因素与生物学因素的交互在BPD发病中的作用。 Borderline personality disorder (BPD), which is characterized by persistent and pervasive cognitive, emotional, and behavioral dysregulation, is among the most severe and perplexing behavioral disorders. From the developmental psychopathology approach, Borderline personality disorder is associated with psychological and social risk factors including poor family environments during childhood, disrupted attachment relationships and family history factors, and it is related to dysfunctional neurotransmitter systems, including serotonin, dopamine and so on. It is also related to dysfunction of frontolimbic circuitry and the peripheral nervous system. Most importantly, the emergence of BPD was the results of the interaction between environmental risk factors and vulnerable neurobiological factors across development. Future researches about pathogenetic mechanisms of the borderline personality disorder should focus on longitudinal or developmental studies and examine the role of the interaction between environmental risk factors and neurobiological factors in BPD from other fields and more comprehensive assessments of more methods.
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