Curcumin-Loaded Bio-Based Electrospun Polyurethane Scaffolds

摘要

Polimerik elektroe?irme lifler, yara iyile?me uygulamalar? i?in iyi tasar?ml? iskeleler sunmaktad?r. Burada, kurkumin (Cur) i?eren biyobazl? poliüretan (PU) kar???m liflerin üretimi rapor edilmektedir. Y aln?zca polimer konsantrasyonu de?il, ayn? zamanda kurkumin konsantrasyonu, fiberlerin morfolojisi, ?ap? ve temas a??s? de?erlerini etkilemi?tir. Morfolojik ara?t?rmalar, PU liflerinin ?ap?n?n ve hidrofilikli?inin kurkumin ilavesi üzerine artt???n? ortaya koymu?tur. Proses parametrelerinin (uygulanan voltaj, ak?? h?z? ve u?tan toplay?c?ya mesafe) PU ve PU/Cur liflerinin ortalama ?ap ve hidrofilikli?i üzerindeki etkileri incelenmi?tir. Homojen ve boncuksuz PU/Cur lif elde etmek i?in optimum ko?ullar 12.5 kV, 1 mL/s ve 17 cm olarak belirlenmi?tir. Bu ?al??ma, elektroe?irme i?leminin, biyoaktif madde yüklü lifli iskeleleri elde etmenin basit bir yolunu sa?lamas?n?n yan? s?ra, PU/Cur kar???m liflerinin imalat?nda yara iyile?mesi uygulamalar? i?in i?lem de?i?kenlerinin etkisinin daha iyi anla??lmas?na katk?da bulundu?unu g?stermektedir. Polymeric electrospun fibers present well-design scaffolds for wound healing applications. Here, the fabrication of biobased polyurethane (PU) blend fibers containing curcumin (Cur) was reported. Not only polymer concentration but also curcumin concentration affects the morphology, diameter, and contact angle values of the fibers. Morphological investigations revealed that the diameter and hydrophilicity of the PU fibers increased upon addition of curcumin. Effect of process parameters (applied voltage, flow rate, and tip-to-collector distance) on the average diameter and the hydrophilicity of the PU and PU/Cur fibers were examined. Optimum conditions to obtain uniform and bead-free PU/Cur fibers were determined as 12.5 kV, 1 mL/h, and 17 cm. This study demonstrates that the electrospinning process provides a simple way of obtaining bioactive agent loaded fibrous scaffolds, as well as contributing to a better understanding of the effect of process variables in the fabrication of PU/Cur blend fibers for wound healing applications.