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Current Pharmacological and Nonpharmacological Options for the Management of Insomnia

机译:目前用于治疗失眠的药理学和非药理学选择

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Insomnia continues to be a major public health concern and to have a pronounced and detrimental effect on health care costs, productivity, and quality of life. Efficacious pharmacological and nonpharmacological interventions have emerged over the past few decades, giving providers several options for addressing this disruptive condition; these are herein reviewed.Benzodiazepines have long been the pharmacological treatment of choice for insomnia; however, novel hypnotics being developed by the pharmaceutical industry show promise in addressing insomnia with fewer side effects. From the nonpharmacological perspective, several different single-component interventions such as stimulus control have been shown to be effective, although a combination of these approaches (eg, cognitive-behavioral therapy for insomnia) also enjoy strong empirical support. Future research should continue to examine how sequencing of treatment components, treating different patient cohorts, and combinations of pharmacological and nonpharmacological treatments influence patient outcome.
机译:失眠仍然是主要的公共卫生问题,并且对医疗保健成本,生产力和生活质量产生了明显而有害的影响。在过去的几十年中,已经出现了有效的药理学和非药理学干预措施,为医疗服务提供者提供了多种选择来应对这种破坏性疾病。长期以来,苯二氮卓类药物一直是失眠的首选药物治疗方法。然而,制药业开发的新型催眠药显示出以更少的副作用解决失眠的前景。从非药物学的角度来看,虽然将这些方法(例如,针对失眠的认知行为疗法)结合使用,但已显示出几种不同的单组分干预措施(例如刺激控制)是有效的,但也得到了有力的经验支持。未来的研究应继续研究治疗成分的测序,治疗不同患者队列以及药理学和非药理学治疗的组合如何影响患者的预后。

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