Effect evaluation of the feeding, and administration of omeprazole pellets orally on gastric juice pH in adult horses

摘要

The aim of this study was to determine the omeprazol treatment effect on equine gastric fluid pH with food and without food administering for the duration of the experiment. To carry this project out, 7 animals were chosen between the ages of 3 and 10 (2 males and 5 females) from the Centro de Veterinaria y Zootecnia - CES. In the controlled treatment they received 200 ml of physiological saline and were treated using omeprazol pellets which were administered in a single dose of 4 mg/kg via a nasogastric insertion, and in two groups with or without food during the treatment. Gastric pHs were measured at 0 hour (fasting before treatment) and then at hours 3, 5, 7, 9, 11 and 24 after treatment. In animals consuming food, both treatments showed post treatment gastric pH increases, which can be explained by the ad libitumn food management in both treatments, which may increasing post prandial pH. In fasting animals, we observed that in the controlled treatment the pH was maintained at very low levels at all measurement times, while in the omeprazol treatment the pH increased significantly. These results show that treatment with omeprazol pellets at a dose of 4 mg/kg via nasogastric insertion increased gastric pH in healthy animals that are not eating food and that this effect was similar to them being administered food.