Invasive Thyroglossal Duct Cyst Papillary Carcinoma: A Case Report and Review of the Literature

摘要

Objective: Rare diseaseBackground: Thyroglossal duct cyst is a common congenital anomaly of the thyroid gland, usually found centrally. The pres-ence of malignancy occurring in a thyroglossal duct cyst is a rare condition, accounting only for 1% of all cases of thyroglossal duct cyst. This report is of a rare case of papillary carcinoma arising in a thyroglossal duct cyst and includes a review of the literature.Case Report: A 27-year-old female patient was referred to our department with a painless cystic mass in the neck. After ini-tial physical examination and endocrinology investigations, a fine needle aspiration (FNA) of the cyst was per-formed. Cytology showed a papillary neoplasm. The patient underwent total thyroidectomy and surgical exci-sion of the thyroglossal duct cyst (the Sistrunk’s procedure). Histopathology of the surgical excision specimen showed a thyroglossal duct cyst with a maximum diameter of 7.5 cm containing a primary invasive papillary carcinoma, measuring 1.5 cm in diameter that infiltrated into the cyst wall. The remaining thyroid gland was normal.Conclusions: Thyroglossal duct carcinoma, most commonly papillary carcinoma, is a rare condition that should be consid-ered in patients presenting with cystic midline neck masses. Surgery and complete excision is the main treat-ment and the optimal patient management includes multidisciplinary consultation in order to improve surviv-al. The diagnosis of malignancy is made postoperatively, as in the present case.