Relationship between Helicobacter pylori Adenotonsillar Colonization and Frequency of Adenotonsillitis in Children

摘要

Background: There are insufficient data in the literature on the presence of Helicobacter pylori in tonsil and adenoid tissue of patients with only airway obstruction. This study examined the presence of H. pylori in surgical cases with airway obstruction or recurrent infection. Aims: To investigate the relationship between H. pylori adenotonsillar colonisation and the frequency of adenotonsillitis and to compare paediatric and adult patients according to H. pylori tonsillar colonisation. Study Design: Prospective clinical trial. Methods: Patients scheduled for adenoidectomy or tonsillectomy were classified into three groups based on indications: paediatric infection (n=29), paediatric obstruction (n=29) and adult infection (n=12). Tissue samples obtained from patients were examined for the presence of H. pylori by culture, rapid urease test and polymerase chain reaction. Results: Forty-nine tonsil tissues were examined. Positive results were found in two specimens with the rapid urease test (4.1%) and three with polymerase chain reaction examination (6.1%). Only three positive polymerase chain reaction results (5.8%) were identified in 52 adenoid tissue samples. There were no statistically significant differences in the presence of H. pylori between paediatric infection and obstruction groups or between paediatric infection and adult infection groups. Conclusion: In our study, there was a low incidence of H. pylori colonisation in tonsil and adenoid tissues. Regarding H. pylori colonisation, there was no significant difference between paediatric infection and obstruction groups. Also, no significant difference was found between adult and paediatric cases. Turkish Ba?l?k: Adenotonsiller Helicobacter pylori kolonizasyonu ile Adenotonsilit S?kl??? Aras?ndaki ?li?ki Anahtar kelimeler: Helicobacter pylori, adenoid, tonsil, kolonizasyon, Enfeksiyon s?kl???, PCR Arkaplan: Literatürde sadece hava yolu obstrüksiyonu olan olgularda tonsil ve adenoid dokuda Helicobacter pylori( H.pylori )varl??? ile ilgili yeterli bilgi bulunmamaktad?r. Bu ?al??mada obstrüksiyon veya reküren enfeksiyon nedeniyle cerrahi uygulanan olgularda H.pylori varl??? incelenmi?tir. Ama?: Adenotonsiller dokuda H.pylori colonizasyonu ile adenotonsilit s?kl??? aras?ndaki ili?kiyi incelemek, pediatrik ve eri?kin olgular? tonsil dokusunda H.pylori kolonizasyonu a??s?ndan kar??la?t?rmak. ?al??ma Tasar?m?: Prospektif klinik ?al??ma, ü?üncü basamak sa?l?k merkezi Y?ntemler: Adenoidektomi ve tonsilektomi planlanan olgular endikasyonlar?na g?re ü? gruba ayr?ld?: pediatrik enfeksiyon (n=29), pediatrik obstrüksiyon (n=29) ve eri?kin enfeksiyon (n=12). Olgulardan toplanan doku ?rnekleri, h.pylori varl??? a??s?ndan kültür, rapid urease test ve polimeraz zincir reaksiyonu (PCR) ile incelendi. Bulgular: 49 tonsil dokusu incelendi. Rapid urease test ile iki olguda (%4.1) ve PCR ile ü? olguda (%6.1) pozitif sonu? al?nd?. 52 adenoid doku ?rne?inden sadece ü? olguda(%5.8) PCR ile pozitif sonu? al?nd?. Hem pediatrik enfeksiyon ile obstrüksiyon gruplar? hem de pediatrik ve eri?kin enfeksiyon gruplar? H.pylori varl??? a??s?ndan kar??la?t?r?lmas?nda istatistiksel olarak farkl?l?k tespit edilmedi. Sonu?: ?al??mam?zda tonsil ve adenoid dokuda H.pylori kolonizasyonunun insidans?n?n dü?ük oldu?u belirlendi. H.pylori kolonizasyonu a??s?ndan pediatrik enfeksiyon ve obstrüksiyon gruplar? aras?nda anlaml? bir farkl?l?k bulunmad?. Ayr?ca pediatric ve yeti?kin olgular aras?nda da farkl?l?k bulunmad?.