Effect of mannitol on the pharmacokinetics of amikacin in wistar rats

Alfonso Alfaro Rodríguez

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Effect of mannitol on the pharmacokinetics of amikacin in wistar rats

机译：甘露醇对阿米卡星对wistar大鼠药代动力学的影响

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The study analyzed the effect of mannitol on the pharmacokinetics (PK) of amikacin. Adult Wistar rats were treated as follows: Group 1 (G1) received mannitol for three days, Group 2 (G2) received mannitol plus 10 mg/kg of amikacin simultaneously, and Group 3 only amikacin. The PK study was conducted on the 4th day. For which, blood samples were drawn at fixed times during 24 h and immunoenzymatically analyzed. Results revealed significant differences (p

机译：该研究分析了甘露醇对丁胺卡那霉素的药代动力学（PK）的影响。成年Wistar大鼠的治疗方法如下：第1组（G1）接受甘露醇三天，第2组（G2）同时接受甘露醇加10 mg / kg阿米卡星，第3组仅接受阿米卡星。 PK研究在第4天进行。为此，在24小时内的固定时间抽取血样并进行免疫酶分析。结果显示出显着差异（p

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《Brazilian Archives of Biology and Technology》 |2009年第4期|共5页
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Alfonso Alfaro Rodríguez;
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1. Effect of Mannitol on the Pharmacokinetics of Amikacin in Wistar Rats [J] . Juarez Olguin Hugo, Carrasco Portugal Miriam, Flores Perez Janett, Brazilian Archives of Biology and Technology . 2009,第4期

机译：甘露醇对阿米卡星对Wistar大鼠药动学的影响
2. Simultaneous Administration of Amikacin and Mannitol Prolongs The Latencies in Waves III-V in The Rat's Brainstem Auditory Response [J] . Alfonso ALFARO-RODRIGUEZ, Rigoberto GONZáLEZ-PI?A, Emilio ARCH-TIRADO, Journal of neurological sciences (Turkish) . 2011,第4期

机译：阿米卡星和甘露醇的同时给药延长了大鼠脑干听觉反应中III-V波的潜伏期
3. Simultaneous Administration of Amikacin and Mannitol Prolongs The Latencies in Waves III-V in The Rat's Brainstem Auditory Response [J] . Alfonso ALFARO-RODRIGUEZ, Rigoberto GONZáLEZ-PI?A, Emilio ARCH-TIRADO, Journal of neurological sciences (Turkish) . 2011,第4期

机译：阿米卡星和甘露醇的同时给药延长了大鼠脑干听觉反应中III-V波的潜伏期
4. Light Microscopy Study of the Aortic Depressor Nerve: Comparison between Wistar (WR), Wistar-Kyoto (WKY) and Spontaneously Hypertensive Rats (SHR). [C] . de Aguiar Mendes Vania Alice, Menezes de Amorim Milena, Oliveira Xery da Silva Leticia, International Symposium on Morphological Sciences . 2012

机译：主动脉减压神经的光学显微镜研究：Wistar（WR），Wistar-kyoto（WKY）和自发性高血压大鼠（SHR）的比较。
5. Comparative study of TRPM5 in pancreatic beta-cells of Wistar Kyoto and Goto Kakizaki rats. [D] . Monteilh-Zoller, Mahealani. 2015

机译：Wistar Kyoto和Goto Kakizaki大鼠胰腺β细胞中TRPM5的比较研究。
6. The pharmacokinetics of 14C-edrophonium in normal wistar rats and homozygous gunn rats with ligated renal pedicles [O] . D.J. Back, T.N. Calvey 1974

机译：结扎肾蒂的正常wistar大鼠和纯合性gunn大鼠中14C-旋风ium的药代动力学
7. Effect of Mannitol on the Pharmacokinetics of Amikacin in Wistar Rats [O] . Hugo Juárez Olguín, Miriam Carrasco Portugal, Janett Flores Pérez, 2015

机译：甘露醇对Wistar大鼠阿米卡星药代动力学的影响

Effect of mannitol on the pharmacokinetics of amikacin in wistar rats

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