Theophylline Toxicity – A Forgotten Entity

摘要

It is often forgotten that smoking inducescytochrome P450 (CYP) 1A2, resulting in altered concentrations and required doses of drugs metabolized by this route. Conversely, upon cessation of smoking, concentrations of these drugs can rise to toxic levels unless appropriate dose adjustments are made. Medical staff, and others involved with smoking cessation counselling, need to be aware of this if potential harm to patients is to be avoided. Here, we describe a patient who developed tonic clonic seizures due to Theophylline toxicity, having ceased smoking 2 weeks earlier.