Background There is a growing interest in the role of the endothelium in migraine. Recently, our group showed differences in endothelial function between the anterior and posterior cerebral circulation in healthy subjects, reduced vasodilatatory capacity of the posterior cerebral circulation and unimpaired systemic endothelial function in migraine patients without comorbidities. However, the relationship between cerebral and systemic endothelial function and the anterior and posterior cerebral endothelial function in migraine patients is still not clear. Methods We compared cerebral and systemic endothelial function through post-hoc linear regression analysis of cerebrovascular reactivity (CVR) to L-arginine between the middle cerebral artery (MCA) and flow-mediated vasodilatation (FMD) of the right brachial artery and the posterior cerebral artery (PCA) and FMD in migraine patients without comorbidities and in healthy subjects. The anterior and posterior cerebral endothelial function was also compared using post-hoc linear regression analysis between CVR to L-arginine in the MCA and the PCA. Results No significant correlation was found between CVR to L-arginine in the MCA and FMD and in the PCA and FMD in migraine patients with aura (p = 0.880 vs. p = 0.682), without aura (p = 0.153 vs. p = 0.179) and in healthy subjects (p = 0.869 vs. p = 0.662). On the other hand, we found a significant correlation between CVR to L-arginine in the MCA and PCA in migraine patients with aura (p = 0.004), without aura (p = 0.001) and in healthy subjects (p = 0.002). Detailed analysis of the linear regression between all migraine patients and healthy subjects did not show any difference in the regression coefficient (slope) (p = 0.382). However, a significant difference in curve elevation (intercept) was found (p = 0.002). Conclusions Our study suggests that the endothelial function in the cerebral and systemic circulation might be different in migraine patients without comorbidities, while that of the anterior and posterior cerebral circulation might be coupled. These results could improve understanding of endothelial function in migraine patients without comorbidities.
展开▼
机译：背景技术内皮在偏头痛中的作用越来越受到关注。最近，在没有合并症的偏头痛患者中，我们的研究组显示了健康受试者的前，后脑循环之间的内皮功能差异，后脑循环的血管舒张能力降低以及系统内皮功能未受损。然而，偏头痛患者的脑和系统内皮功能与大脑前后血管内皮功能之间的关系仍不清楚。方法我们通过大脑中部动脉（MCA）和右臂肱后动脉血流介导的血管舒张（FMD）之间对L-精氨酸的脑血管反应性（CVR）的事后线性回归分析，比较了脑和系统内皮功能无合并症的偏头痛患者和健康受试者的动脉（PCA）和FMD。使用MCA和PCA中CVR与L-精氨酸之间的事后线性回归分析，还比较了大脑前后的内皮功能。结果在没有先兆的偏头痛患者中，MCA和FMD的CVR与L-精氨酸之间以及PCA和FMD之间无显着相关性（p = 0.880 vs. p = 0.682），无先兆（p = 0.153 vs. p = 0.179） ）和健康受试者（p = 0.869 vs. p = 0.662）。另一方面，我们发现具有先兆的偏头痛患者（p = 0.004），没有先兆的偏头痛患者（p = 0.001）和健康受试者（p = 0.002）在MCA和PCA中CVR与L-精氨酸之间存在显着相关性。所有偏头痛患者与健康受试者之间线性回归的详细分析未显示回归系数（斜率）有任何差异（p = 0.382）。但是，发现曲线高程（截距）存在显着差异（p = 0.002）。结论我们的研究表明，在没有合并症的偏头痛患者中，脑和系统循环中的内皮功能可能有所不同，而脑前和后循环中的内皮功能可能是相关的。这些结果可以增进对无合并症的偏头痛患者对内皮功能的了解。
展开▼
