Biomechanical Modeling of Prosthetic Mesh and Human Tissue Surrogate Interaction

摘要

Surgical repair of hernia and prolapse with prosthetic meshes are well-known to cause pain, infection, hernia recurrence, and mesh contraction and failures. In literature, mesh failure mechanics have been studied with uniaxial, biaxial, and cyclic load testing of dry and wet meshes. Also, extensive experimental studies have been conducted on surrogates, such as non-human primates and rodents, to understand the effect of mesh stiffness, pore size, and knitting patterns on mesh biocompatibility. However, the mechanical properties of such animal tissue surrogates are widely different from human tissues. Therefore, to date, mechanics of the interaction between mesh and human tissues is poorly understood. This work addresses this gap in literature by experimentally and computationally modeling the biomechanical behavior of mesh, sutured to human tissue phantom under tension. A commercially available mesh (Prolene?) was sutured to vaginal tissue phantom material and tested at different uniaxial strains and strain rates. Global and local stresses at the tissue phantom, suture, and mesh were analyzed. The results of this study provide important insights into the mechanics of prosthetic mesh failure and will be indispensable for better mesh design in the future.