A comparison between the effects of propofol–fentanyl with propofol–ketamine for sedation in patients undergoing endoscopic retrograde cholangiopancreatography outside the operating room

摘要

Background The efficient and secure techniques of anesthesia and sedation have always been needed for. One of these procedures is endoscopic retrograde cholangiopancreatography (ERCP), due to its painfulness and long duration, has high sensitivity. We compare the effects of propofol–fentanyl (PF) with propofol–ketamine (PK) to sedate patients undergoing ERCP. Methods In this clinical trial, patients were divided into two groups of 49 people. A group?received a pharmaceutical combination of PK, and another group received a pharmaceutical combination of PF. Vital signs of patients, Ramsey Sedation Score, and pain of patients were assessed. The total dosage of used propofol was also recorded. Results There was no significant difference seen in the patients' hemodynamic characteristics in both groups. Pain at the end of surgery and an hour after it in the {PK} group was less that was?not statistically significant. By Ramsey Sedation Score also significant differences were not seen between groups (p?=?0.68). By using total dose of propofol used also a significant difference?was not observed between the two groups (p?=?0.36). Rate of apnea in {PK} group was 32% and in the {PF} group was 63%, which this difference was statistically significant (p?