Bifunctional dentifrice: Amorphous polyphosphate a regeneratively active sealant with potent anti-Streptococcus mutans activity

摘要

Objective: In this study we demonstrate that inorganic polyphosphate (polyP) exhibits a dual protective effect on teeth: it elicits a strong antibacterial effect against the cariogenic bacterium Streptococcus mutans and, in form of amorphous calcium polyP microparticles (size of 100-400nm), it efficiently reseals cracks/fissures in the tooth enamel and dentin. Methods: Three different formulations of amorphous polyP microparticles (Ca-polyP, Zn-polyP and Sr-polyP) were prepared.