Is There a Role for Neoadjuvant Chemotherapy Without Radiotherapy in Locally Advanced Rectal Cancer?

Andrea Cercek; Karyn A. Goodman

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Is There a Role for Neoadjuvant Chemotherapy Without Radiotherapy in Locally Advanced Rectal Cancer?

机译：不进行放疗的新辅助化疗在局部晚期直肠癌中有作用吗？

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The treatment paradigm for locally advanced rectal cancer is multidisciplinary and includes chemoradiotherapy and surgery followed by adjuvant chemotherapy. This review discusses the rationale behind multimodality treatment, the role of radiotherapy, and the potential for its omission in selected patients in the future.

机译：局部晚期直肠癌的治疗范例是多学科的，包括放化疗和手术后再进行辅助化疗。这篇综述讨论了多模式治疗背后的原理，放疗的作用以及将来在某些患者中可能省略的可能性。

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来源
《Current Colorectal Cancer Reports》 |2013年第2期|126-129|共4页
作者
Andrea Cercek; Karyn A. Goodman;
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作者单位

Department of Medicine Memorial Sloan-Kettering Cancer Center">(1);

Department of Radiation Oncology Memorial Sloan-Kettering Cancer Center">(2);

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原文格式 PDF
正文语种 eng
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关键词
Rectal cancer; Pelvic radiotherapy; Induction chemotherapy; FOLFOX; Chemotherapy; Long-term quality of life; Locally advanced rectal cancer;

机译：直肠癌;骨盆放疗;诱导化疗;FOLFOX;化学疗法长期的生活质量;局部晚期直肠癌;

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专利

1. Randomized phase II study comparing the efficacy and safety of SOX versus mFOLFOX6 as neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer (KSCC1301) [J] . Keisuke Miwa, Eiji Oki, Masanobu Enomoto, BMC Cancer . 2021,第1期

机译：随机期II研究将SOX与Mfolfox6的疗效和安全性比较为Neoadjuvant化疗，无需放疗局部晚期直肠癌（KSCC1301）
2. Neoadjuvant Chemotherapy With mFOLFOXIRI Without Routine Use of Radiotherapy for Locally Advanced Rectal Cancer [J] . Zhang Jianwei, Huang Meijin, Cai Yue, Clinical colorectal cancer . 2019,第4期

机译：与Mfolfoxiri的Neoadjuvant化疗无需常规使用放疗局部晚肠癌
3. A Multicenter Phase 2 Study on the Feasibility and Efficacy of Neoadjuvant Chemotherapy Without Radiotherapy for Locally Advanced Rectal Cancer [J] . Suguru Hasegawa, Saori Goto, Takuya Matsumoto, Annals of surgical oncology . 2017,第12期

机译：多中心第2期关于Neoadjuvant化疗无放射治疗的可行性和功效研究局部晚期癌症
4. Neoadjuvant treatment in rectal cancer: do we always need radiotherapy-or can we risk assess locally advanced rectal cancer better? [C] . Rob Glynne-Jones St. Gallen EORTC Gastrointestinal Cancer Conference . 2012

机译：Neoadjuvant在直肠癌中治疗：我们总是需要放射治疗 - 或者我们是否可以更好地评估当地先进的直肠癌？
5. Intenzivnej?e neoadjuvantno zdravljenje lokalno napredovalnega raka danke =Intensified neoadjuvant treatment of locally advanced rectal cancer [D] . Golo, Danijela. 2018

机译：强烈的Neoadjuvant治疗局部晚期癌症射线=加强Neoadjuvant治疗局部晚期直肠癌
6. Randomized phase II study comparing the efficacy and safety of SOX versus mFOLFOX6 as neoadjuvant chemotherapy without radiotherapy for locally advanced rectal cancer (KSCC1301) [O] . Keisuke Miwa, Eiji Oki, Masanobu Enomoto, 2021

机译：随机期II研究将SOX与MfolfoX6的疗效和安全性进行比较因为没有放射治疗的Neoadjuolvant化疗用于局部晚期直肠癌（KSCC1301）
7. Randomized Phase II Study Comparing the Efficacy and Safety of SOX versus mFOLFOX6 as Neoadjuvant Chemotherapy without Radiotherapy for Locally Advanced Rectal Cancer (KSCC1301) [O] . Keisuke Miwa, Eiji Oki, Masanobu Enomoto, 2020

机译：随机期II研究将SOX与MfolfoX6的疗效和安全性进行比较，因为没有放射治疗的Neoadjuolvant化疗，用于局部晚期直肠癌（KSCC1301）

Is There a Role for Neoadjuvant Chemotherapy Without Radiotherapy in Locally Advanced Rectal Cancer?

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