Venous thromboembolism, fetal loss and preeclampsia in pregnant women with congenital thrombophilia

摘要

Thromboembolic events are now recognized as being a major health problem in adults. In the last two decades, the discovery of several congenital abnormalities of hemostasis that predispose to venous thromboembolic events have led to search for optimal strategies for the prevention and treatment of thromboembolism second- ary to congenital prothrombotic disorders. The identi- fied main causes of inherited thrombophilia are anti- thrombin, protein C and protein S deficiency, the factor V Leiden mutation accounting for activated protein C (APC)resistance, the G20210A mutation of the pro- thrombin gene and the thermolabile variant of 5,10- methylenetetrahydrofolate reductase(C667T MTHFR).