Clinical Observation on Antiruisi Prescription in Preventing Restenosis after Coronary Artery Stenting

摘要

Modern studies proved that garlic used in the AR prescription could lower blood lipids, depress blood platelet and coagulation, lower blood sugar, dilate blood vessels and reduce blood pressure. Also it could increase the relaxing factors originating from endothelium and blood smooth muscles, inhibit the proliferation of smooth muscles, control the genesis and development of arteriosclerosis after blood vessel damage, inhibit the infiltration of LDL into vascular intima and the oxygen free radical induced vascular damage. Rhubarb can reduce blood pressure, improve the haemorrheologi-cal state of blood, lower blood lipids, antagonise inflammation and lower the blood glucose, and its effective component, emodin, can inhibit the proliferation of smooth muscles in vitro. Leech has the effects of anti-coagulation, anti-thrombosis, reducing blood lipids, improving the haemorrheo-logic state of blood, dissipating atheromatous plaque, lowering the mRNA expression of endo-thelin in vivo, and inhibiting the proliferation of smooth muscles in vitro. Combined use of these three drugs can influence multiple links of coronary restenosis to prevent restenosis formation.