Comment on 'Concentration and distribution of dioxins and related compounds in human tissues' by Takao Iida, Takashi Todaka,Hironori Hirakawa, Tsuguhide Hori, Kazuhiro Tobiishi, Takahiko Matsueda, Shaw Watanabe, Taketo Yamada [Chemosphere 67/9 (2007) S26

摘要

We suspect that a significant strength of the paper by Iida et al. (2007) on concentrations of dioxins and related compounds in human tissues went unmentioned by the authors: theirs might the first study ever to report concentrations of such compounds in the human pancreas. If this is not so, we would appreciate readers bringing the appropriate papers to our attention; naturally, we have searched such evidence for years. The issue is relevant, in particular, because studies have suggested that some organochlorine compounds might increase the risk of pancreatic cancer (Porta et al., 1999; Hoppin et al., 2000; Li et al., 2005; Fryzek et al., 2005). Iida et al. found that levels were somewhat higher in the lungs and pancreas (18 patients) than in other sites; we certainly think Iida et al. are right to state that further data must be accumulated from a more extensive and representative group of human samples. Additional organochlorine compounds would also need to be analyzed (e.g., non-coplanar polychlorinated biphenyls, dichlorodiphenyltrichloroethane, dichlorodiphenyldichloro-ethane).