Correlations between dechlorane plus concentrations in paired hair and indoor dust samples and differences between dechlorane plus isomer concentrations in hair from males and females

摘要

Dechlorane plus (DP) is found widely in environmental media. Determining DP concentrations in dust and hair and identifying relationships between the concentrations in dust and hair could improve our understanding of the effects of DP in humans. DP concentrations in 48 hair samples from male and female students and in 30 indoor dust samples from dormitories and classrooms used by the students were determined. The objective was to determine the difference of DP concentration between indoor dust and hair, and to explore the effect of DP in dust on DP in hair of male and female students. The mean DP concentration was significantly higher in male dormitory dust than female dormitory dust, and the estimated DP dose through exposure to dust was also significantly higher for males than females. However, the mean DP concentration was significantly higher for hair from females than from males. The median DP f(anti) was significantly lower for hair than dust, indicating DP may be stereoselectively metabolized by humans. The median DP f(anti) was significantly higher for hair from females than from males, indicating DP may be metabolized differently by males and females. Human serum albumin preferred combination with anti-DP, rather than syn-DP. DP in indoor dust was not a major direct source of the DP in the hair, meaning DP in hair mainly came from within the body. There may be significant differences in DP, particularly anti-DP, metabolism in males and females. (C) 2019 Elsevier Ltd. All rights reserved.