An Approach To Biodegradable Star Polymeric Architectures Using Disulfide Coupling

摘要

The straightforward synthesis of biodegradable star polymers via both in situ polymerization from a trifunctional RAFT agent and post-polymerization conjugation of pyridyldisulflde-ended linear polymers to a trithiol precursor is described.rnMulti-armed star polymeric architectures have attracted increasing interest due to their potential applications in a number of areas, e.g. encapsulation, sensing, catalysis, electronics, optics, biological engineering, coatings, additives, drug- and gene delivery. Generally speaking, these complicated architectures could be achieved by 'arm-first' or 'core-first' methodologies. Recently, the more straightforward "core-first" strategy has drawn an increasing interest for generating multi-armed polymeric architectures in a more controllable mode.