Disulfide-cross-linked Peg-poly(amino Acid)s Copolymer Micelles For Glutathione-mediated Intracellular Drug Delivery

摘要

We report biocompatible, cell-permeable core-shell-corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.rnRecent advances in stimuli-responsive self-assemblies have led to the development of smart nanocarriers that can trigger the release of bioactive agents, such as drugs, genes, and proteins, in response to specific cellular signals. In this area, one of the most desirable approaches for enhanced therapeutic efficacy is the development of nanocarriers that can meet the following requirements: (i) maintaining high structural stability in blood, (ii) eliminating undesirable drug release before reaching the target site, and (iii) releasing drugs specifically within target cells. Of many potent nanocarriers, polymer micelles assembled from amphiphilic diblock or triblock co-polymers have been a research target of great significance for targeted intracellular drug delivery.