Covalent modification of a metal-organic framework with isocyanates: probing substrate scope and reactivity

摘要

Isoreticular metal-organic framework-3 (IRMOF-3) has been postsynthetically modified with isocyanates to generate unprecedented, microporous urea-functionalized frameworks.rnThe open structures of metal-organic frameworks (MOFs) have been shown to sequester molecules as small as H_2 and as large as C_(60), suggesting that the voids within these materials can accommodate guests in a liquid-like state. Indeed, Robson and Hoskins suggested more than a decade ago that the channels within these materials would be able to accommodate reagents that could react with the framework. Recently, our group and others have demonstrated that reactive molecules can access these cavities such that the MOF components can be chemically modified to generate structures with new functionality.