ynthesis of a new spiro-BOX ligand and its application in enantioselective allylic cyclization based on carbopalladation of allenyl hydrazines

摘要

In this paper, we developed a new bisoxazoline ligand with a spiro skeleton and a α-naphthylmethyl substituent, i.e. (R_a,S,S)-L3, which has been successfully applied to the highly enantioselective cyclic allylation based on the carbopalladation of 3,4-allenyl hydrazines with ee values ranging from 92-95%.rnTransition metal-catalyzed asymmetric allylic substitution of allylic acetate or carbonates is a well-established process for the highly enantioselective formation of carbon-carbon or heteroatom bonds.