Poly-β-cyclodextrin based platform for pH mapping via a ratiometric ~(19)F/~1H MRI method

Eliana Gianolio; Roberta Napolitano; Franco Fedeli; Francesca Arena; Silvio Aime

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Poly-β-cyclodextrin based platform for pH mapping via a ratiometric ~(19)F/~1H MRI method

机译：基于聚-β-环糊精的平台，可通过比率〜（19）F /〜1H MRI方法进行pH定位

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The in vitro validation of a new pH mapping MRI method based on a supramolecular poly-β-cyclodextrin-~(19)F-Gd adduct is reported. Mapping pH is an important task in medical imaging as changes in pH usually accompany the development of various pathologies such as tumours, strokes and infections. Several attempts to map pH by MRI have been reported.

机译：报道了一种基于超分子聚-β-环糊精-〜（19）F-Gd加合物的新型pH映射MRI方法的体外验证。绘制pH值是医学成像中的重要任务，因为pH值的变化通常伴随着各种病理的发展，例如肿瘤，中风和感染。已经报道了通过MRI绘制pH图的几种尝试。

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《Chemical Communications》 |2009年第40期|6044-6046|共3页
作者
Eliana Gianolio; Roberta Napolitano; Franco Fedeli; Francesca Arena; Silvio Aime;
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Dept. of Chemistry IFM and Molecular Imaging Center, Via Nizza 52, Torino, Italy;

Dept. of Chemistry IFM and Molecular Imaging Center, Via Nizza 52, Torino, Italy;

Dept. of Chemistry IFM and Molecular Imaging Center, Via Nizza 52, Torino, Italy;

Dept. of Chemistry IFM and Molecular Imaging Center, Via Nizza 52, Torino, Italy;

Dept. of Chemistry IFM and Molecular Imaging Center, Via Nizza 52, Torino, Italy;

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Poly-β-cyclodextrin based platform for pH mapping via a ratiometric ~(19)F/~1H MRI method

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