Copper-catalyzed aerobic phosphonation of sp~3 C-H bonds

摘要

An efficient cross-dehydrogenative-coupling (CDC) between sp~3 C-H and H-P bonds was developed using copper salt as catalyst and molecular oxygen as terminal oxidant; this new methodology provides an easy access to biologically important α-aminophosphonates.rnα-Aminophosphonates and their corresponding α-amino-phosphonic acids have received much interest in organic and medicinal chemistry because they are analogous to both natural and unnatural amino acids. Moreover, α-amino-phosphonates have broad applications due to their antibacterial, antifungal, enzyme inhibitory and catalytic antibody activities.