Transition-metal-catalyzed regioselective aroyl- and trifluoro-acetylthiolation of alkynes using thioesters

摘要

Intermolecular CO-retained carbothiolation of alkynes using thioesters took place to afford β-SR substituted enone derivatives; the choice of catalyst (Pd(dba)_2-dppe) and the introduction of a CF_3 group into the thioesters are the key to achieving the transformation.rnThe development of efficient transition-metal-catalyzed carbon-heteroatom bond-forming reactions has been one of the most important subjects in synthetic chemistry. An important example would be the addition reactions of carbon-heteroatom bonds across C-C unsaturated bonds that form new carbon-carbon bonds in a single procedure. A wide range of substrates having C-S, C-Se, C-N, C-Si, C-Sn and C-B bonds were employed for this purpose.