Fluorinase mediated chemoenzymatic synthesis of [~(18)F]-fluoroacetate

Xiang-Guo Li; Juozas Domarkas; David OHagan

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Fluorinase mediated chemoenzymatic synthesis of [~(18)F]-fluoroacetate

机译：氟化酶介导的[〜（18）F]-氟乙酸的化学合成

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A novel preparation of sodium [~(18)F]-fluoroacetate is described where 5'-[~(18)F]-fluoro-5'-deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-L-methionine (SAM) with no carrier added [~(18)F]-fluoride and then oxidation to [~(18)F]-fluoroacetate by a Kuhn-Roth oxidative degradation.

机译：描述了一种新颖的[〜（18）F]-氟乙酸钠制剂，其中S'-腺苷-L-蛋氨酸的氟化酶催化反应生成了5'-[〜（18）F]-氟-5'-脱氧腺苷（在没有载体的情况下添加[〜（18）F]-氟化物，然后通过Kuhn-Roth氧化降解将其氧化为[〜（18）F]-氟乙酸盐。

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来源
《Chemical Communications》 |2010年第41期|p.7819-7821|共3页
作者
Xiang-Guo Li; Juozas Domarkas; David OHagan;
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University of St Andrews, School of Chemistry and Centre forBiomolecular Sciences, North Haugh, St Andrews, Fife, KY16 9ST,UK Department of Pharmacology, Drug Development and Therapeutics/Laboratory of Synthetic Drug Chemistry, Institute of Biomedicine,University of Turku, Lemminkaisenkatu 5C, 20520 Turku, Finland;

rnJohn Mallard Scottish PET Centre, School of Medical Sciences,University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK;

rnUniversity of St Andrews, School of Chemistry and Centre forBiomolecular Sciences, North Haugh, St Andrews, Fife, KY16 9ST,UK;

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Fluorinase mediated chemoenzymatic synthesis of [~(18)F]-fluoroacetate

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