Indium catalyzed tandem hydroamination/hydroalkylation of terminal alkynesf

摘要

The first direct intermolecular hydroamination/hydroalkylation of terminal alky nes catalyzed by In(OTf)_3 under one-pot conditions leading to the formation of conjugated ketimines in good yields is described. In recent years, considerable effort has been devoted to develop methodologies which reduce multi-step transformations into one-step tandem processes In this regard, the use of multifunctional catalysts, which promote sequential reaction steps without additional requirement of additives and/or co-catalysts, provides an effective way while taking care of two most basic challenges faced by a synthetic chemist, i.e. atom-economy and cost-reduction.2 The addition of N-H and C-H bonds across C-C ti systems, also known as hydroamination and hydroalkylation, is one of the most interesting and intriguing subjects in synthetic organic chemistry, as they provide an attractive route for construction of a plethora of versatile building blocks. A variety of efficient catalytic systems have been developed for hydroamination of alkynes.