Photodimerisation of glycothymidines in solution and in micelles

摘要

Glycothymidines were designed and synthesized as a new class of functional glycomimetics in which a photochemical [2 + 2) cycloaddition of the thymine moiety induces structural changes of carbohydrate presentation. To test if photodimerisation of these glycothymidines is feasible within an array of molecules, the photochemical reaction was investigated using NMR and NMR diffusion experiments in solution as well as in the supra-molecular context of detergent micelles that mimic cellular membranes.