Resonance light scattering as a powerful tool for sensitive detection of β-amyloid peptide by gold nanoparticle probesf

摘要

A novel biosensing strategy has been developed for sensitive detection of p-amyloid 1-42 (Aβ_(1-42) down to the ng mL~(-1) level in both aqueous solution and diluted human plasma, which is based on measuring changes in resonance light scattering of streptavidin functionalized gold nanoparticles as a function of the concentration of Aβ_(1-42) with a conventional spectrofluorometer.