Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

Fabien W. Monnard; Tillmann Heinisch; Elisa S. Nogueira; Tilman Schirmer; Thomas R. Ward

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Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

机译：人碳酸酐酶II作为带有磺酰胺锚的钢琴凳配合物的宿主

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d~6-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II). The 1.3 A resolution X-ray crystal structure of |(η~6-C_6Me_6)Ru(bispy 3)C1]~+ hCA II highlights the nature of the host-guest interactions.

机译：带有芳基磺酰胺锚的d〜6-钢琴凳复合物对人碳酸酐酶II（hCA II）表现出亚微摩尔的亲和力。 |（η〜6-C_6Me_6）Ru（bispy 3）C1] + hCA II的1.3 A分辨率X射线晶体结构突出了宿主与客体相互作用的性质。

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《Chemical Communications》 |2011年第29期|p.8238-8240|共3页
作者
Fabien W. Monnard; Tillmann Heinisch; Elisa S. Nogueira; Tilman Schirmer; Thomas R. Ward;
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Department of Chemistry, University of Basel, Spitalstrasse 51,CH-4056 Basel, Switzerland;

Department of Chemistry, University of Basel, Spitalstrasse 51,CH-4056 Basel, Switzerland,Biozentrum, University of Basel, Klingelbergstrasse 50170,CH-4056 Basel, Switzerland;

Department of Chemistry, University of Basel, Spitalstrasse 51,CH-4056 Basel, Switzerland;

Biozentrum, University of Basel, Klingelbergstrasse 50170,CH-4056 Basel, Switzerland;

Department of Chemistry, University of Basel, Spitalstrasse 51,CH-4056 Basel, Switzerland;

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Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor

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