The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA_C receptor

Izumi Yamamoto; Meredith J. T. Jordan; Navnath Gavande; Munikumar R. Doddareddy; Mary Chebib; Luke Hunter

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The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA_C receptor

机译：syn-2,3-二氟-4-氨基丁酸的对映体在GABA_C受体处引发相反的反应

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The conformational behaviour and GABA receptor activity of the different stereoisomers of 2,3-difluoro-4-aminobutyric acid are described. Two enantiomeric GABA_c-active ligands are identified, one of which is an agonist while the other is an antagonist. The results support an existing QSAR model of the bioactive geometry of GABA at GABA_C.

机译：描述了2,3-二氟-4-氨基丁酸不同立体异构体的构象行为和GABA受体活性。确定了两个对映体GABA_c活性配体，其中一个是激动剂，另一个是拮抗剂。该结果支持了GABA_C下GABA生物活性几何结构的现有QSAR模型。

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《Chemical Communications》 |2012年第6期|p.829-831|共3页
作者
Izumi Yamamoto; Meredith J. T. Jordan; Navnath Gavande; Munikumar R. Doddareddy; Mary Chebib; Luke Hunter;
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Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia;

School of Chemistry, The University of Sydney, NSW 2006, Australia;

Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia;

Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia;

Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia;

School of Chemistry, The University of Sydney, NSW 2006, Australia,School of Chemistry, The University of New South Wales, NSW 2052, Australia;

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The enantiomers of syn-2,3-difluoro-4-aminobutyric acid elicit opposite responses at the GABA_C receptor

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