The iron-catalyzed construction of 2-aminopyrimidines from alkynenitriles and cyanamides

摘要

Several cycloaddition catalysts and reagents were surveyed for their effectiveness toward cyclizing alkynenitriles with cyanamides. Catalytic amounts of Fel_2, ~(IPr)PDAI and Zn were found to effectively catalyze the [2+2+2] cydoaddition of a variety of cyanamides and alkynenitriles to afford bicyclic 2-aminopyrimidines.