Pd-catalysed direct dehydrogenative carboxylation of alkenes: facile synthesis of vinyl esters

摘要

A novel Pd-catalysed oxidative coupling reaction methodology using readily available carboxylic acids and alkenes for the preparation of vinyl esters has been developed. A broad range of vinyl esters were successfully synthesised. The reactions have demonstrated good efficiency as well as excellent chemo- and regio-selectivity. Vinyl esters present a class of useful organic building blocks which have been utilized in polymer chemistry, chemical industry and pharmaceutical sciences. Various traditional processes for the synthesis of these motifs have been established.