Flash generation of α-(trifluoromethyl)vinyllithium and application to continuous flow three-component synthesis of α-trifluoromethylamides

摘要

α-(Trifluoromethyl)vinyllithium was generated and used for the reaction with electrophiles at -78 ℃ in a flow microreactor although the batch reaction should be carried out at ca. -100 ℃, and the method was applied to continuous flow three-component synthesis of α-trifluoromethylamides.