The perils of rational design - unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

Maksims Yevglevskis; Guat L. Lee; Michael D. Threadgill; Timothy J. Woodman; Matthew D. Lloyd

首页> 外文期刊>Chemical Communications >The perils of rational design - unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

【24h】

The perils of rational design - unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

机译：合理设计的风险-由α-甲基酰基辅酶A外消旋酶（AMACR; P504S）催化的3-氟-2-甲基酰基辅酶A意外地不可逆地消除氟化物

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

α-Methylacyl-CoA racemase (AMACR; P504S) catalyses 'racemization' of 2-methylacyl-CoAs, the activation of R-ibuprofen and is a promising cancer drug target Human recombinant AMACR 1A catalyses elimination of 3-fluoro-2-methyldecanoyl-CoAs to give E-2-methyldec-2-enoyl-CoA and fluoride anion, a previously unknown reaction. 'Racemization' of 2-methyldec-3-enoyt-CoAs was also catalysed, without double bond migration.

机译：α-甲基酰基辅酶A消旋酶（AMACR; P504S）催化2-甲基酰基辅酶A的'消旋'，R-布洛芬的活化，是一种有前途的癌症靶标人类重组AMACR 1A催化消除3-氟-2-甲基癸酰基- CoAs生成E-2-甲基癸-2-烯酰基-CoA和氟化物阴离子，这是以前未知的反应。还催化了2-甲基dec-3-enoyt-CoA的“团聚”，没有双键迁移。

著录项

来源
《Chemical Communications》 |2014年第91期|14164-14166|共3页
作者
Maksims Yevglevskis; Guat L. Lee; Michael D. Threadgill; Timothy J. Woodman; Matthew D. Lloyd;
展开▼
作者单位

Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK;

Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK;

Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK;

Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK;

Medicinal Chemistry, Department of Pharmacy & Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY, UK;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S [J] . LloydM.D., YevglevskisM., LeeG.L., Progress in Lipid Research: An International Journal . 2013,第2期

机译：α-甲基酰基辅酶A消旋酶（AMACR）：代谢酶，药物代谢物和癌症标志物P504S
2. Synthesis And Use Of Isotope-labelled Substrates For A Mechanistic Study On Human α-methylacyl-coa Racemase 1a (amacr; P504s) [J] . Daniel J. Darley, Danica S. Butler, Samuel J. Prideaux, Organic & biomolecular chemistry . 2009,第3期

机译：同位素标记底物的合成和用途，用于人α-甲基酰基-Coa消旋酶1a（amacr; P504s）的机理研究
3. Sertoli cell tumor of the testis, not otherwise specified, presenting extensive hemorrhage and overexpression of α-methylacyl-CoA racemase (AMACR/P504S) [J] . Katsuaki Sato, Hironori Tachibana, Shojiroh Morinaga, Virchows Archiv . 2007,第3期

机译：睾丸支持细胞肿瘤（未特别说明）表现出大量出血和α-甲基酰基辅酶A消旋酶（AMACR / P504S）的过度表达
4. The perils of rational design – unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S) [O] . Jevglevskis Maksims, Lee Guat L., Threadgill Michael D., 2014

机译：合理设计的风险–由α-甲基酰基辅酶A外消旋酶（AMACR; P504S）催化的3-氟-2-甲基酰基辅酶A意外地不可逆地消除氟化物

The perils of rational design - unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S)

摘要

著录项

相似文献

相关主题

期刊订阅