A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding

John B. Mangrum; Brigitte J. Engelmann; Erica J. Peterson; John J. Ryan; Susan J. Berners-Price; Nicholas P. Farrell

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A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding

机译：靶向聚糖的新方法：寡糖金属屏蔽抑制酶

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Metalloglycomics - the effects of defined coordination compounds on oligosaccharides and their structure and function - opens new areas for bioinorganic chemistry and expands its systematic study to the third major class of biomolecules after DNA/RNA and proteins.

机译：金属糖化学-定义的配位化合物对寡糖及其结构和功能的影响-开辟了生物无机化学的新领域，并将其系统研究扩展到仅次于DNA / RNA和蛋白质的第三大类生物分子。

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《Chemical Communications》 |2014年第31期|4056-4058|共3页
作者
John B. Mangrum; Brigitte J. Engelmann; Erica J. Peterson; John J. Ryan; Susan J. Berners-Price; Nicholas P. Farrell;
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Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, USA;

Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, USA;

Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, USA;

Department of Biology, Virginia Commonwealth University, Richmond, Virginia 23284, USA;

Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia;

Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, USA ,Institute for Glycomics, Griffith University, Gold Coast, Queensland 4222, Australia;

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1. Active Site Mapping of Xylan-Deconstructing Enzymes with Arabinoxylan Oligosaccharides Produced by Automated Glycan Assembly [J] . Deborah Senf, Colin Ruprecht, Goswinus H. M. de Kruijff, Chemistry: A European journal . 2017,第13期

机译：用自动化聚糖组件制备的阿拉伯解构酶的活性位点测绘酶联糖苷
2. Matrix-assisted laser desorption/ionization in-source decay combined with tandem time-of-flight mass spectrometry of permethylated oligosaccharides: targeted characterization of specific parts of the glycan structure [J] . Wuhrer M, Deelder AM Rapid Communications in Mass Spectrometry: RCM . 2006,第6期

机译：基质辅助激光解吸/电离源内衰减结合全甲基化低聚糖的串联飞行时间质谱：聚糖结构特定部分的目标表征
3. Cyanovirin-N defines a new class of antiviral agent targeting N-linked, high-mannose glycans in an oligosaccharide-specific manner. [J] . Bolmstedt AJ, OKeefe BR, Shenoy SR, Molecular pharmacology. . 2001,第5期

机译：Cyanovirin-N定义了一种以寡糖特异性方式靶向N-连接的高甘露糖聚糖的新型抗病毒剂。
4. Significance of enzyme degradation rate andenzyme inhibition in targeted chemotherapy [C] . George Weber International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2004

机译：酶降解率和酶抑制在靶向化疗中的意义
5. Alleviating Cancer Drug Toxicity Through Targeted Inhibition of a Bacterial Enzyme and Exploring the Structural and Functional Properties of the Xenobiotic Nuclear Receptor PXR. [D] . Wallace, Bret David. 2012

机译：通过有针对性地抑制细菌酶来缓解癌症药物的毒性，并探索异种核受体PXR的结构和功能特性。
6. A New Approach to Glycan Targeting. Enzyme Inhibition by Oligosaccharide Metalloshielding [O] . John B. Mangrum, Brigitte J. Engelmann, Erica J. Peterson, -1

机译：聚糖靶向的新方法。寡糖金属屏蔽对酶的抑制
7. A new approach to glycan targeting: Enzyme inhibition by oligosaccharide metalloshielding [O] . Mangrum John B., Engelmann Brigitte J., Peterson Erica J., 2014

机译：针对聚糖的新方法：寡糖金属屏蔽抑制酶

A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding

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