Asymmetric alkylation of dimethoxyphosphoryl-N-[1-(S)-alpha-methylbenzyl]acetamide enolates. Synthesis of both stereoisomers from the same source of chirality by changing the equivalents of LDA

Ordonez M; Hernandez-Fernandez E; Xahuentitla J; Cativiela C

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Asymmetric alkylation of dimethoxyphosphoryl-N-[1-(S)-alpha-methylbenzyl]acetamide enolates. Synthesis of both stereoisomers from the same source of chirality by changing the equivalents of LDA

机译：二甲氧基磷酰基-N- [1-（S）-α-甲基苄基]乙酰胺烯酸酯的不对称烷基化。通过改变LDA的当量，从相同的手性来源合成两种立体异构体

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摘要

A new methodology has been developed for the synthesis of both stereoisomers from a single chiral source.

机译：已经开发了用于从单一手性源合成两种立体异构体的新方法。

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来源
《Chemical Communications》 |2005年第10期|p. 1336-1338|共3页
作者
Ordonez M; Hernandez-Fernandez E; Xahuentitla J; Cativiela C;
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作者单位

Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca 62210, Morelos, Mexico;

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原文格式 PDF
正文语种 eng
中图分类化学;
关键词
ENANTIOSELECTIVE TRANSFER HYDROGENATION; BETA-AMINOPHOSPHINE OXIDES; ALPHA-AMINO; ACIDS; DERIVATIVES; PHOSPHONATES; LIGANDS; GLYCINE; KETONES;

机译：对映选择性加氢;BET-氨基膦氧化物;α-氨基;酸;衍生物;磷酸盐;配体;甘氨酸;酮;

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1. A Novel Chiral Pentamine Ligand fro Enantioselective #alpha#-Alkylation of Acyclic Lithium Amide Enolates. Optimization of Chiral Ligands for Asymmetric Reactions Using Solid-Phase Organic Synthesis [J] . Jun-ichi Matsuo, Kazunori Odashima, Shu Kobayashi Organic letters . 1999,第2期

机译：一种新型的手性五聚氰胺配体，用于无环酰胺化锂烯醇盐的对映选择性＃alpha＃-烷基化。固相有机合成优化不对称反应的手性配体
2. Expedient Asymmetric Synthesis of (S)-2-Amino-4,4,4-trifluorobutanoic Acid via Alkylation of Chiral Nucleophilic Glycine Equivalent [J] . Mei Haibo, Hiramatsu Takahiro, Takeda Ryosuke, Organic process research & development . 2019,第4期

机译：（S）-2-氨基-4,4,4-三氟丁酸的有利不对称合成通过手性亲核甘氨酸等同物的烷基化
3. Asymmetric synthesis of sterically and electronically demanding linear ω-trifluoromethyl containing amino acids via alkylation of chiral equivalents of nucleophilic glycine and alanine [J] . Wang J., Lin D., Zhou S., The Journal of Organic Chemistry . 2011,第2期

机译：通过亲核甘氨酸和丙氨酸的手性当量的烷基化，不对称合成空间和电子要求的线性含ω-三氟甲基线性氨基酸
4. Asymmetric Amino Acid Synthesisby the Asymmetric Alkylation of Glycine Derivativeswith Chiral Spiro-Type and SimplifiedPhase-Transfer Catalysts [C] . Keiji Maruoka ACS symposium asymmetric synthesis and application of α-amino acids . 2009

机译：不对称氨基酸合成来自甘氨酸衍生物的不对称烷基化，With Chiral螺型和简化的晶态转移催化剂
5. A general method for the asymmetric synthesis of quaternary carbons: Reductive formation and alkylation of alpha,alpha-disubstituted enolates. [D] . Manthorpe, Jeffrey Michael. 2003

机译：季碳不对称合成的一般方法：α，α-二取代烯酸酯的还原形成和烷基化。
6. Construction of Tertiary Chiral Centers by Pd-catalyzed Asymmetric Allylic Alkylation of Prochiral Enolate Equivalents [O] . Yusuke Kita, Yoshitaka Numajiri, Noriko Okamoto, -1

机译：Pd催化前手性烯醇盐当量的不对称烯丙基烷基化反应构建第三级手性中心
7. Construction of Tertiary Chiral Centers by Pd-catalyzed Asymmetric Allylic Alkylation of Prochiral Enolate Equivalents [O] . Kita Yusuke, Numajiri Yoshitaka, Okamoto Noriko, 2015

机译：Pd催化前手性烯醇盐当量的不对称烯丙基烷基化反应，构建第三级手性中心

Asymmetric alkylation of dimethoxyphosphoryl-N-[1-(S)-alpha-methylbenzyl]acetamide enolates. Synthesis of both stereoisomers from the same source of chirality by changing the equivalents of LDA

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