A novel fluorine-metal exchange reaction of pentafluorocrotonate with organocuprate. Generation of β-metallated tetrafluorocrotonate and its cross-coupling reaction

摘要

Fluorine-metal exchange reaction of 2,3,4,4-,4-pentafluorocro-tonates with organocuprate derived from Grignard reagent and CuCN takes place efficiently to generate the β-metallated tetrafluorocrotonate intermediate, which reacts with various electrophiles to give β-substituted 2,4,4,4-tetrafluorocrotonates.