A Single Bolus of a Long-acting Erythropoietin Analogue Darbepoetin Alfa in Patients with Acute Myocardial Infarction: A Randomized Feasibility and Safety Study

Erik Lipšic; Peter van der Meer; Adriaan A. Voors; B. Daan Westenbrink; Ad F. M. van den Heuvel; Hetty C. de Boer; Anton J. van Zonneveld; Regien G. Schoemaker; Wiek H. van Gilst; Felix Zijlstra; Dirk J. van Veldhuisen

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A Single Bolus of a Long-acting Erythropoietin Analogue Darbepoetin Alfa in Patients with Acute Myocardial Infarction: A Randomized Feasibility and Safety Study

机译：急性心肌梗死患者长效促红细胞生成素类似物达比泊汀α的单剂：随机可行性和安全性研究

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摘要

Aims: Besides stimulating hematopoiesis, erythropoietin (EPO) protects against experimental ischemic injury in the heart. The present study evaluated the safety and tolerability of EPO treatment in non-anemic patients with acute myocardial infarction (MI).

机译：目的：除刺激造血作用外，促红细胞生成素（EPO）还可以保护心脏免受实验性缺血性损伤。本研究评估了非贫血急性心肌梗死（MI）患者使用EPO的安全性和耐受性。

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来源
《Cardiovascular Drugs and Therapy》 |2006年第2期|135-141|共7页
作者
Erik Lipšic; Peter van der Meer; Adriaan A. Voors; B. Daan Westenbrink; Ad F. M. van den Heuvel; Hetty C. de Boer; Anton J. van Zonneveld; Regien G. Schoemaker; Wiek H. van Gilst; Felix Zijlstra; Dirk J. van Veldhuisen;
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作者单位

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Department of Nephrology and Hypertension Leiden University Medical Center University of Leiden The Netherlands;

Department of Nephrology and Hypertension Leiden University Medical Center University of Leiden The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

Departments of Cardiology University Medical Center Groningen University of Groningen The Netherlands;

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正文语种 eng
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关键词
acute myocardial infarction; erythropoietin; endothelial progenitor cells;

机译：急性心肌梗死;促红细胞生成素;内皮祖细胞;

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1. A single-center prospective randomized controlled trial evaluating the safety and efficacy of IntraCoronary Erythropoietin delivery BEfore Reperfusion: Gauging infarct size in patients with acute ST-segment elevation myocardial infarction. Study design and rationale of the 'ICEBERG Trial' [J] . SuhJ.-W., YoonY.E., OhI.-Y., Contemporary clinical trials . 2013,第1期

机译：一项单中心前瞻性随机对照试验，评估再灌注前冠状动脉内促红细胞生成素的安全性和有效性：评估急性ST段抬高型心肌梗死患者的梗死面积。 “ ICEBERG试用”的研究设计和原理
2. Single-dose intravenous administration of recombinant human erythropoietin is a promising treatment for patients with acute myocardial infarction - randomized controlled pilot trial of EPO/AMI-1 study -. [J] . Ozawa T, Toba K, Suzuki H, Circulation journal . 2010,第7期

机译：单剂量静脉内注射重组人促红细胞生成素是急性心肌梗死患者的有前途的治疗方法-EPO / AMI-1研究的随机对照先导试验。
3. Single-Dose Intravenous Administration of Recombinant Human Erythropoietin Is a Promising Treatment for Patients With Acute Myocardial Infarction – Randomized Controlled Pilot Trial of EPO/AMI-1 Study – [J] . Takuya Ozawa, Ken Toba, Hiroshi Suzuki, Circulation journal . 2010,第7期

机译：重组人促红细胞生成素的单剂量静脉内给药是急性心肌梗死患者的有希望的治疗方法– EPO / AMI-1研究的随机对照试验–
4. Enhancing Prediction Models for One-Year Mortality in Patients with Acute Myocardial Infarction and Post Myocardial Infarction Syndrome [C] . Seyedeh Neelufar Payrovnaziri, Laura A. Barrett, Daniel Bis, MEDINFO . 2019

机译：增强急性心肌梗死患者一年死亡率的预测模型和心肌梗死综合征
5. Understanding off-label utilization patterns of two biotechnology drugs, recombinant erythropoietin alfa and darbepoetin alfa: A multi-hospital study. [D] . Patkar, Anuprita D. 2005

机译：了解两种生物技术药物的标签外利用模式：重组促红细胞生成素α和darbepoetin alfa：一项多院研究。
6. A multicenter prospective randomized controlled trial evaluating the safety and efficacy of intracoronary cell infusion mobilized with granulocyte colony-stimulating factor and darbepoetin after acute myocardial infarction: study design and rationale of the MAGIC cell-5-combination cytokine trial [O] . Hyun-Jae Kang, Min-Kyung Kim, Myung-Gon Kim, 2011

机译：一项多中心前瞻性随机对照试验评估急性心肌梗塞后动员粒细胞集落刺激因子和达比泊汀动员的冠状动脉内输注的安全性和有效性： MAGIC细胞5结合细胞因子试验的研究设计和原理
7. Prediction of 1-Year Clinical Outcomes Using the SYNTAX Score in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention A Substudy of the STRATEGY (Single High-Dose Bolus Tirofiban and Sirolimus-Eluting Stent Versus Abciximab and Bare-Metal Stent in Acute Myocardial Infarction) and MULTISTRATEGY (Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study) Trials [O] . Garg Scot, Sarno Giovanna, Serruys Patrick W., 2011

机译：急性ST段抬高型心肌梗死接受原发性经皮冠状动脉介入治疗的急性ST段抬高型心肌梗死患者使用SYNTAX评分预测1年临床结果急性心肌梗死）和多策略（急性心肌梗死研究中单一高剂量小肠替罗非班与阿昔单抗联合西罗莫司洗脱支架或裸金属支架的多中心评估）试验

A Single Bolus of a Long-acting Erythropoietin Analogue Darbepoetin Alfa in Patients with Acute Myocardial Infarction: A Randomized Feasibility and Safety Study

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