Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions: H. Pylori infection, histological types and staging

摘要

AIM To investigate the expression of multiple genes and the behavior of cellular biology in gastric cancer 9GC) and other gastric mucosal lesions and their relations to Helicobacter pylori H. pylori) infection, bumor staging and Histological subtypes. METHODS Three hundred and twenty-seven Specimens of gastric mucosa obtained via Endoscopy or surgical resection, and ABC Immunohistochemical staining were used to Detect the expression of p53, p16, Bcl-2 and COX-2 proteins.