Stimulation by nizatidine, a histamine H_2-receptor antagonist, of duodenal HCO_3 secretion in rats: relation to anti-cholinesterase activity

摘要

AIM To examine whether nizatidine stimulates duodenal HCO_3 secretion in rats by inhibiting AchE activity. METHODS Under pentobarbital anesthesia, a Proximal duodenal loop was perfused with Saline, and the HCO_3 secretion was measured At pH 7.0 using a pH-stat method and by adding 10 mM HCI. Nizatidine, neostigmine, carbachol or famotidine was administered i.v. as a single injection.