The role of endotoxin, TNF-α, and IL-6 in inducing the state of growth hormone insensitivity

摘要

CONCLUSION: The growth hormone insensitivity could be induced by LPS injection, which was associated with down- regulated GHR mRNA expression at receptor level and with up-regulated SOCS-3 mRNA expression at post-receptor level. The in vivo biological activities of LPS were mediated by TNF-α and IL-6 indirectly, and TNF-α and IL-6 may exert their effects on. the receptor and post-receptor levels respectively. AIM: Critical illnesses such as sepsis, trauma, and burns cause a growth hormone insensitivity, which leads to an increased negative nitrogen balance. Endotoxin is generously released into blood under these conditions and stimulates the production of proinflammatory cytokines such as TNF-α, IL-6, and IL-1, which may play a very important role in inducing the growth hormone insensitivity.