Similarities of hydrolytic antibodies revealed by their X-ray structures: A review

摘要

Numerous antibodies have been programmed to catalyse the hydrolysis of esters as well as other acyl transfer reactions. They were raised against stable analogues that model the structure of the tetrahedral transition states of these reactions. The three-dimensional structures of four hydrolytic antibodies complexed to their respective phosphonate transition state analogues (TSAs) reveal a similar orien- tation of hapten relative to the antibody.