Antibacterial Synergistic Activity of Ofloxacin and Ornidazole Treated Biomedical Fabrics against Nosocomial Pathogens

摘要

Microbial damage of fabrics and microbial-contaminated fabrics are known to be the major source of nosocomial cross-infections in hospitals. The hospital fabrics possess susceptible surface properties to harbour diverse group of bacteria. The main aim of this study is to treat the fabric materials using two groups of antibacterial drug combinations based on their synergistic behaviour. Hence for the first time synergistic ofloxacin and ornidazole drugs were covalently bound to the textile materials using reactive dye method. Using the standard AATCC Test Method-100 the antibacterial activity and durability of drug treated textile materials was evaluated before and after wash. Drug treated textile materials (before wash) showed maximum percentage of reduction with a reduction percentage of 90% for E. coli (nylon) and 92.85% for S. aureus (polyester). After 5th wash, the treated textile materials showed maximum reduction percentage of 63.4% for E. coli (nylon) and 64.1% for S. aureus (nylon). The development of antibacterial textile finish in the study could have the possibility to eliminate the drug resistance properties of hospital based nosocomial pathogens.