Lower Respiratory Illnesses Promote FEV_1 Decline in Current Smokers But Not Ex-Smokers with Mild Chronic Obstructive Pulmonary Disease

摘要

We analyzed Lung Health Study (LHS) data to assess the effect of self-reported lower respiratory illnesses resulting in physician vis- its (LRI) on lung function. Participants were 5, 887 smokers aged 35-60 yr, FEV_1/FVC < 0.70 and FEV_1 of 55-90/100 predicted. Two- thirds were randomized into an intensive smoking cessation pro- gram (SI); one-third were advised only to stop smoking (UC). For 5 yr participants had annual spirometry and questioning regard- ing LRI.