The role of ventilatory-control abnormalities in predisposing to familial sleep-disordered breathing (SDB) was assessed in 31 subjects 28 ± 10 yr of age (mean ± SD). Subjects with (n = 10) and without SDB (n = 12) were recrutied from 13 families having two or more members with SDB. Nine age- and Gender-matched controls were recruited from families having no member with SDB. Respiratory re- Sponses to eucapnic hypoxia, and ventilatory and occlsion pressure responses to hyperoxic hyper- Capnia with and without added resistive loads (6.5 cm H_2O/L/s), were assessed through rebreathing.
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机译:通风控制异常在易患家族性睡眠呼吸障碍(SDB)中的作用已在31位年龄为28±10岁(平均±SD)的受试者中进行了评估。从(n = 10)和没有SDB(n = 12)的受试者中招募了拥有两个或更多SDB成员的13个家庭。从没有SDB成员的家庭中招募了9个年龄和性别匹配的对照。通过呼吸来评估对高氧血症低氧的呼吸反应,以及在有和没有增加阻力负荷(6.5 cm H_2O / L / s)时对高氧高碳酸血症的通气和阻塞压力反应。
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